Supporting Complex Cell & Gene Therapy Trials in Israel

Cell and Gene Therapy (CGT) is transforming the treatment landscape for patients with serious and life-threatening disease. Unlike traditional therapies, these highly personalised treatments often involve living cells and biological materials that must be handled under exceptionally strict conditions. Every step of the supply chain, from manufacturing and storage to transportation and patient administration, plays a critical role in ensuring treatment integrity and, ultimately, patient outcomes.

As CGT clinical trials expand globally, sponsors face increasing operational challenges in managing complex logistics, specialised equipment requirements, and local regulatory considerations. Success depends not only on maintaining the cryogenic supply chain but also on ensuring that clinical sites have immediate access to the ancillary materials and equipment needed to treat patients safely and on schedule.

This was the challenge faced by a global biotechnology company conducting an advanced Cell & Gene Therapy study in Israel.

Challenge

The sponsor was running a highly complex LN2-based Cell & Gene Therapy study in Israel requiring not only cryogenic storage and distribution, but also rapid access to specialised ancillary equipment and locally sourced products essential for patient treatment.

In Cell & Gene Therapy studies, patient treatment windows are often tightly defined, leaving little room for delays or supply disruptions. The sponsor needed a trusted local partner capable of coordinating multiple moving parts while ensuring every component was available exactly when required.

The challenge included:

• Procurement of highly specialised medical equipment and consumables within Israel;
• Ensuring compatibility of all ancillary materials with clinical protocols;
• Coordinating multiple suppliers while maintaining strict timelines;
• Supporting LN2 storage and handling requirements for temperature-sensitive investigational products;
• Reducing operational burden for the sponsor by providing a single local point of contact.

 Oximio’s Solution

Oximio acted as a local partner in Israel, providing an end-to-end procurement and logistics solution to support the study.

Working as an extension of the sponsor’s team, we coordinated the sourcing, qualification, and delivery of critical materials while ensuring alignment with patient treatment programs and protocol requirements.

Our support included:

• Local procurement and supply of specialised equipment and ancillary materials
• Vendor qualification and supplier management
• Coordination of delivery timelines aligned with patient treatment schedules
• Integration of locally sourced products into the clinical supply chain
• Support for LN2 storage and handling activities

Examples of locally procured materials included:

• Cryogenic water bath for LN2 product thawing
• Lymphodepletion supportive medications
• Ultra-low temperature freezer
• Laboratory water bath with solid lid
• Syringe Pump SYS-3010
• Central Venous Catheterization Kits
• Original Perfusor N infusion lines

By managing procurement locally and coordinating multiple suppliers through a single operational framework, we helped ensure that critical equipment and consumables were available when and where they were needed.

Outcome

The study was supported through a streamlined local solution that reduced complexity and helped maintain operational continuity throughout the trial.

• Successful support of Cell & Gene Therapy operations in Israel
• Timely availability of all critical equipment and ancillary materials
• Reduced complexity for the sponsor through a single local service provider
• Improved study continuity and patient readiness
• Demonstrated Oximio’s capability to support highly specialised LN2 and Cell & Gene Therapy trials beyond traditional depot services

Key Value Delivered

As Cell & Gene Therapy trials continue to expand into new markets, sponsors increasingly require partners who can do more than simply store and distribute investigational products. A successful outcome depends on finding the right partner who can bridge global clinical supply strategies with local execution.

Oximio goes beyond traditional depot services by acting as an integrated local partner, enabling sponsors to navigate complex Cell & Gene Therapy requirements through procurement, logistics, and operational expertise. By combining cryogenic supply chain capabilities with local market knowledge and supplier management, we were able to help the sponsor maintain focus on what matters most – delivering innovative therapies to their patients.

Comparator Sourcing for Clinical Trials

With a global footprint, Oximo’s comparator sourcing extends worldwide. Utilising our expert marketing knowledge and experience, we secure the best cost and quickest lead times to provide the highest quality medicinal and ancillary products.

Visit our website to view our comparator sourcing medicinal product list or contact us to discuss your requirements. We’d be delighted to assist you with your research.